Clinical study on the outcome of renal transplantation in patients with systemic autoimmune disease
- VernacularTitle:自身免疫病患者肾移植术后的临床研究
- Author:
Yawang TANG
;
Yuhai ZHANG
- Publication Type:Journal Article
- From:
Chinese Journal of Organ Transplantation
2001;22(1):11-13
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the outcome of renal transplantation in the patients with systemi c autoimmune disease. Method The clinical data of 25 patients with autoimmune disease undergoing renal transp lantation were retrospectively analyzed. Results The survival rate for 1 year, 3 years, 5 years after renal transplantation in t he patients with autoimmune disease and without autoimmune disease were 88 .0 %, 80.0 %, 72.0 % and 88.9 %, 84.4 %, 77.8 % r espectively. The graft survival rate for 1 year,3 years, 5 years after renal tra nsplantation in the patients with autoimmune disease and without autoimmune dise ase were 84.0 %, 72.0 %, 60.0 % and 86.2 %, 77.0 %, 66.4 % respectively. The average intervals of dialysis pre-transplantati on b etween the patients with recurrent underlying diseases (4 patients) and with out recurrent underlying diseases (21 patients) was not difference. Among the 4 p atients with positive ANA and elevated anti-dsDNA serology pre- and post-tr ansp lant, 2 patients had recurrent underlying diseases. Conclusions Renal transplantation should be offered to th e patients with autoimmune diseases because relapses of underlying diseases after renal transplantation seem to be rare. The patient and graft survival rate was not significantly differen t in the patients with autoimmune diseases and without autoimmune diseases.
