BOTH PEPTIDERGIC AND NONPEPTIDERGIC SMALL NEURONS IN RAT DRG EXPRESS GABABR --EVIDENCE FOR PAIN REGULATION BY PRESYNAPTIC MECHANISM IN SPINAL LEVEL
- VernacularTitle:大鼠背根神经节肽能和非肽能小型神经元均表达GABAB受体-脊髓水平突触前痛觉调节机制的证据
- Author:
Ruihe LIN
;
Ruixi LI
;
Jie WANG
;
Qiongying QIAN
;
Lu GAO
;
Liru WU
;
Yuwen PENG
- Publication Type:Journal Article
- Keywords:
pain regulation;
GABAB receptor;
dorsal root ganglion;
spinal dorsal horn;
rat
- From:
Chinese Journal of Neuroanatomy
2006;22(3):267-274
- CountryChina
- Language:Chinese
-
Abstract:
It has been reported that the small type of neurons in the dorsal root ganglion (DRG) play an important role in pain regulation by a presynaptic mechanism via the metabotropic type-B γ-aminobutyric acid receptors ( GABABR ). In order to understand whether the 2populations of the small type of the neurons, peptidergic and nonpeptidergic, in DRG share the same role, immunoflourescent histochemical methods and confocal laser scanning microscope were employed to investigate the expression of the GABABR in the peptidergic and nonpeptidergic small DRG neurons. The results revealed that 92% of the peptidergic and 90% of nonpeptidergic small DRG neurons express GABABR in their perikarya and central processes, which distribute in the various laminae of the spinal dorsal horn. These results suggest both the peptidergic and nonpeptidergic populations of the small neurons in the DRG share similar role in pain modulation via presynaptic mechanisms but in given laminae of the spinal dorsal horn.
