Observation of Chinese herb kangnaoling in improving cognitive and daily living ability of patients with vascular dementia
- VernacularTitle:中药康脑灵改善血管性痴呆患者认知能力及日常生活能力的效果观察
- Author:
Farong ZHANG
- Publication Type:Journal Article
- From:
Chinese Journal of Tissue Engineering Research
2006;10(3):161-163
- CountryChina
- Language:Chinese
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Abstract:
BACKGROUND: The dangerous factors of cerebrovascular disease are also those of vascular dementia (VD). Stasis and retardation of cerebral channels is the basic pathogenesis of VD, kidney-qideficiency is the important pathogenic foundation of VD and therefore the most effective treatment is to stimulate blood circulation to remove stasis, tonify the kidney and improve intellegence.OBJECTIVE: To observe the clinical effects of kangnaoling, a granule traditional Chinese medicine, on the patients with VD. DESIGN: Randomized controlled observation. SETTING: Affiliated Hospital of Shandong University of Traditional Chinese MedicinePARTICIPANTS: Totally 60 patients with VD were selected from Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Zibo City Traditional Chinese Medicine Hospital and the Clinic of Handan Traditional Chinese Medicine Hospital in Hebei Province from May 1998 to October 2001. The patients were randomly divided into experimental group (n=40) and control group (n=20).METHODS: Experimental group: Kangnaoling granules (chief ingredients: gingko leaf, epimeddium and chuanxiong rhizome, etc.) were taken orally,1 pack/time, three times per day. Control group: Naofukang was taken orally, 0.8 g/time, three times per day. The two groups took the medicine both for two months as a course. According to the integral of symptoms and the score in all kinds of scales before and after treatment, the patients were classified into 4 grades: clinically-controlled, remarkable effective, effective and ineffective or worse. Clinically-controlled: The main symptoms in the patients, on the whole, returned to normal. They could well-perform orientation, correctly answer questions, take care of themselves and resume ordinary social activities; remarkable effective: Part of the main symptoms in the patients returned to normal. They could take care of themselves, basically perform orientation, correctly answer questions although their reaction was ordinary. Effective: The main symptoms in the patients were relieved or partly disappeared. Generally, they could take care of themselves, correctly answer questions but their reaction was still slow and had dysfunction in mentality and personality. Ineffective: the main symptoms in the patients were not bettered, even worse. The neuropsychology and cognitive ability of the patients were determined with Mini-Mental State Examination (MMSE) and Hasegawa Dementia Scale (HDS) (total score: 30 points), and the daily living ability of the patients was detected with Functional Activities Questionnaire (FAQ) (It was defined as normal when the score was ≤5 points, and the lower the score was, the better the effect was). MAIN OUTCOME MEASURES: ① The comparison between the two groups in the clinical effect after treatment. ② The comparison between the two groups in the score of MMSE,HDS and FAQ before and after treatment. RESULTS: All the 60 patients were involved in the analysis of results, no one lost. ① The comparison between the two groups in the clinical effect after treatment: The remarkable effective rate was higher in experimental group than in control group (78%, 50%). ② The comparison between the two groups in the score of MMSE, HDS and FAQ before and after treatment: in experimental group, the score of MMSE and HDS was all higher after treatment than before treatment (17.03±5.58, 12.42±3.87; 20.36±6.60,14.73±4.68) while the score of FAQ was lower after treatment than before treatment (10.64±4.58, 15.38±3.37). In control group, the score of HDS was higher after treatment than before treatment (16.82±3.95, 13.20±3.12)while the score of FAQ was lower after treatment than before treatment (11.16±1.06, 14.10±2.15). And the score of HDS was higher in experimental group than in control group after treatment, there was significant difference (P < 0.05).CONCLUSION: Kangnaoling granules and naofukang all have the effect in improving the intellegence of the patients with VD while kangnaoling granules have better clinical effect.