Association between Fibrinogen and Carotid Atherosclerosis According to Smoking Status in a Korean Male Population.
10.3349/ymj.2015.56.4.921
- Author:
Hye Min CHO
1
;
Dae Ryong KANG
;
Hyeon Chang KIM
;
Sun Min OH
;
Byeong Keuk KIM
;
Il SUH
Author Information
1. Department of Public Health, Yonsei University Graduate School, Seoul, Korea.
- Publication Type:Original Article ; Research Support, Non-U.S. Gov't
- Keywords:
Fibrinogen;
smoking;
atherosclerosis;
intima-media thickness
- MeSH:
Adult;
Aged;
Aged, 80 and over;
Asian Continental Ancestry Group/*statistics & numerical data;
Atherosclerosis/*ultrasonography;
Blood Pressure;
Body Mass Index;
Carotid Artery Diseases/*blood/epidemiology/ultrasonography;
Carotid Artery, Common;
*Carotid Intima-Media Thickness;
Cholesterol/blood;
Cholesterol, HDL;
Cross-Sectional Studies;
Fibrinogen/*analysis;
Humans;
Lipoproteins, HDL/blood;
Logistic Models;
Male;
Middle Aged;
Republic of Korea/epidemiology;
Risk Factors;
Sex Factors;
Smoking/*adverse effects/blood/epidemiology;
Surveys and Questionnaires
- From:Yonsei Medical Journal
2015;56(4):921-927
- CountryRepublic of Korea
- Language:English
-
Abstract:
PURPOSE: Although inconsistent, reports have shown fibrinogen levels to be associated with atherosclerosis. Accordingly, since cigarette smoking is associated with increased levels of fibrinogen and atherosclerosis, it may also affect the association between fibrinogen and atherosclerosis. We investigated the associations between fibrinogen and carotid intima-media thickness (IMT) according to smoking status in a Korean male population. MATERIALS AND METHODS: Plasma fibrinogen levels were measured in 277 men aged 40-87 years without a history of myocardial infarction or stroke. High-resolution B-mode ultrasonography was used to examine the common carotid arteries. IMT level was analyzed both as a continuous (IMT-max, maximum value; IMT-tpm, 3-point mean value) and categorical variable (higher IMT; presence of plaque). Serial linear and logistic regression models were employed to examine the association between fibrinogen and IMT according to smoking status. RESULTS: Fibrinogen levels were positively associated with IMT-max (standardized beta=0.25, p=0.021) and IMT-tpm (standardized beta=0.21, p=0.038), even after adjusting for age, body mass index, systolic blood pressure, fasting glucose, and total cholesterol to high-density lipoprotein cholesterol ratio in current smokers (n=75). No significant association between fibrinogen and IMT, however, was noted in former smokers (n=80) or nonsmokers (n=122). Adjusted odds ratios (95% confidence interval) for having plaque per one standard deviation higher fibrinogen level were 2.06 (1.09-3.89) for current smokers, 0.68 (0.43-1.10) for former smokers, and 1.06 (0.60-1.87) for nonsmokers. CONCLUSION: Our findings suggest that cigarette smoking may modify the association between fibrinogen and carotid atherosclerosis. Further studies are required to confirm this finding in different populations.
