The expression of ICAM-1,CEA and CD31 in peritumoral tissues of rectal cancer
- VernacularTitle:直肠癌癌周组织ICAM-1、CEA和CD31的表达
- Author:
Nianming GONG
;
Luwan WEI
;
Yao CHEN
;
Yunhai FANG
;
Ping SUN
;
Zhiyu LIU
- Publication Type:Journal Article
- Keywords:
Rectal neoplasms;
Cell adhesion molecules;
Carcinoembryonic antigen;
CD31
- From:
Chinese Journal of Current Advances in General Surgery
2006;9(3):168-170
- CountryChina
- Language:Chinese
-
Abstract:
Objective:In order to study mechanism of hematogenous metastasis of rectum cancer.Methods:8 specimens of human rectum cancer and 6 specimens of rectum in normal human were examined.The immunohistochemical SP method was employed in study of the expression of ICAM1,CEA and CD31 in the peritumoral rectum tissues and lymphy nodes.Results:The intercellular role in the adhesion molecule-1(ICAM-1)and carcinoma embryonic antigen(CEA) were expressed on the vascular endothelial cells of peritumoral rectum tissues and peritumoral lymph nodes in the rectum cancer.CD31 are expressed on the vascular endothelial cells of rectum tissues from normal human with the same intensity of cancer peritumoral rectum tissues.Conclusion:This study showed that ICAM-1 and CEA seemed to play a stable role in the adhesion effect between cancer cells and endothelial cells.It is not clear whether CD31 plays a role in the interaction between cancer cells and endothelial cells.
