Fitting APD Restitution with Artificial Neural Network
- VernacularTitle:人工神经网络对心肌细胞动作电位时程恢复特性的拟合
- Author:
Xiaodong HAN
;
Zuxiang FANG
;
Cuiwei YANG
;
Xiaomei WU
- Publication Type:Journal Article
- Keywords:
ventricular fibrillation;
Luo-Rudy model;
action potential duration restitution;
artificial neural network
- From:Space Medicine & Medical Engineering
2006;19(5):319-323
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the complex restitution relation between the present action potential duration (APD) and its previous diastole interval (DI) and APD. Method The Luo-Rudy model was paced with different protocols to draw the coordinate curves between the present APD and its first previous DI. These curves were fit with the artificial neural network (ANN). Result Different pacing protocols caused different coordinate curves, and there was no one-to-one relation between pre-sent APD and its first previous DI. ANN fits these curves satisfactorily. Conclusion There is a complex relation between the present APD and the APDs and Dis of the first three previous beats. This relation can be modeled accurately with ANN.
