Stat3 in malignant tumors: research progress
10.3760/cma.j.issn.1673-422X.2011.01.001
- VernacularTitle:Stat3在恶性肿瘤中的研究进展
- Author:
Haidong LI
;
Zhengjun QIU
- Publication Type:Journal Article
- Keywords:
Transcription factor;
Neoplasms;
Neoplasms metastasis;
Tumor infiltrating
- From:
Journal of International Oncology
2011;38(1):3-5
- CountryChina
- Language:Chinese
-
Abstract:
Stat3 is a member of the STAT (signal transducer and activator of transcription) protein family. It can be activated by many cytokines, growth factors and carcinogens. Activation of Stat3 in the cytoplasm leads to its dimerization, translocation into the nucleus, DNA binding and gene transcription. Constitutively activated Stat3 is associated with cellular transformation, invasion, metastasis, angiogenesis, chemoresistance and radioresistance, and therefore suppress apoptosis of cancer.
