Anticoagulant property of a semi-synthesized sodiumβ-1,4-glucan sulfate
- VernacularTitle:半合成β-1,4-葡聚糖硫酸钠的抗凝血特性
- Author:
Zhaomei WANG
;
Lin LI
;
Bing LI
;
Siyuan GUO
- Publication Type:Journal Article
- Keywords:
sodiumβ-1,4-glucan sulfate;
anticoagulation;
action mechanism
- From:
Acta Pharmaceutica Sinica
2006;41(4):323-327
- CountryChina
- Language:Chinese
-
Abstract:
Aim To investigate the anticoagulant efficacy and mechanism of a semi-synthesized sodiumβ-1,4-glucan sulfate (Na-MCS). Methods Anticoagulant activity was evaluated by means of coagulation assays in comparison with heparin. The anticoagulant mechanism of Na-MCS was disclosed by inhibitory analysis of the activities of coagulation factors using chromogenic substrates. Results 0. 6concentration. The dosage of Na-MCS required to double APTT of normal human plasma was 0.7represented a potent anticoagulation activity in vitro, which matched the efficacy of heparin in a certain range of concentrations. Na-MCS exhibited anticoagulant activity due to inhibition of the coagulation factors Ⅱa and Xa by the mediation of anti-thrombin AT-Ⅲ.
