Protective effect of baicalin aganist myocardial ischemia and reperfusion injury in rats
- VernacularTitle:黄芩苷对大鼠心肌缺血再灌注损伤的保护作用
- Author:
Changhan OUYANG
;
Jiliang WU
;
Jinhe CHEN
- Publication Type:Journal Article
- Keywords:
baicalin;
myocardial ischemia;
reperfusion injury;
adenosine triphosphatase;
ventricular function;
creatine kinase;
lactate dehydrogenase
- From:
Chinese Journal of New Drugs and Clinical Remedies
2006;25(6):407-412
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To study the protective effects of baicalin on myocardial ischemia-reperfusion injury in rats. METHODS: The models of myocardial ischemia-reperfusion injury were established by occluding left anterior descending coronary artery (LAD) for 30 min, followed by reperfusion for 120 min. The rate of rise and decline of left ventricular pressure (±dp/dtmax) and end-diastolic pressure of left ventricle (LVEDP) were monitored continuously with polygraph. After reperfusion, the blood and myocardium samples were taken for determination of malondialdehyde (MDA) content, superoxide dismutase (SOD), Na+-K+-ATPase, Ca2+-ATPase activities in myocardium, creatine kinase (CK) and lactate dehydrogenase (LDH) in serum with spectrophotometer. The ultrastructural changes in ischemic myocardium were assessed by transmission electron microscope. RESULTS:dtmax and LVEDP, decreased plasma CK and LDH levels, reduced myocardial MDA content, and increased the activities of SOD, Na+-K+-ATPase, and Ca2+-ATPase in myocardium following ischemia-reperfusion. The ultrastructural injury in reperfused myocardium was relieved. CONCLUSION: Baicalin possesses a protective effect against myocardial ischnemia-reperfusion injury through scavenging oxide radicals and improving Na+-K+-ATPase and Ca2+-ATPase activities.
