Honokiol ameliorates focal cerebral ischemia and enhances tissue reactive oxygen species scavenging capacity after cerebral ischemia-reperfusion
- VernacularTitle:和厚朴酚改善局灶性脑缺血并提高脑缺血再灌注后组织对活性氧的清除能力
- Author:
He HU
;
Zhiyu TANG
;
Shizhong CHEN
;
Yinye WANG
- Publication Type:Journal Article
- Keywords:
honokiol;
cerebral ischemia;
reperfusion injury;
behavior,animal;
peroxidase;
superoxide dismutase
- From:
Chinese Journal of Pharmacology and Toxicology
2006;20(6):455-460
- CountryChina
- Language:Chinese
-
Abstract:
AIM To investigate the effects of honokiol on ischemic neurological deficiency and on the scavenging ability of ischemia reperfusion (I-R) brain tissue for reactive oxygen species (ROS). METHODSCerebral ischemia was induced by middle cerebral artery occlusion (MCAO) in rats. I-R in mice were induced by blood stream pause in bilateral common carotid arteries for 30 min and reperfusion for 30 min. The activities of ROS scavenging enzymes were determined with colorimetric methods. RESULTS Intravenous honokiol in 5-50 μg·kg-1 significantly decreased the neurological deficiency score, and diminished cerebral infarction volume in rats. In I-R brain tissue of mice, intravenous honokiol in 7-70 μg·kg-1 evidently enhanced the activities of superoxide dismutase, catalase, glutathione peroxidase and peroxidase, and markedly lowered lipid peroxidative product malondialdehyde content. Moreover honokiol significantly increased Na+-K+-ATPase activity in I-R brain tissue. CONCLUSION Honokiol ameliorates the neurological deficiency behavior and diminishes infarction volume in MCAO rats; and enhances cerebral scavenging ability for ROS and Na+-K+-ATPase activity in cerebral I-R mice. It is indicated that honokiol is a protective agent for cerebral ischemia and I-R.
