Caffeoylquinic acid derivatives from Bidens parviflora and their antihistamine release activites
- VernacularTitle:小花鬼针草中咖啡酰奎宁酸类成分及其抑制组胺释放活性
- Author:
Jue WANG
;
Naili WANG
;
Xinsheng YAO
;
Susumu KITANGAKA
- Publication Type:Journal Article
- Keywords:
Bidens parviflora Willd.;
caffeoyl quinic acid;
anti-histamine release
- From:
Chinese Traditional and Herbal Drugs
2006;37(7):966-970
- CountryChina
- Language:Chinese
-
Abstract:
Objective Based on the activities of antihistamine release to study the compounds from Bidens parvi-flora and find biological active compounds. Methods The chemical constituents from B.parviflora were isolated by silica gel and Sphadex LH-20 column chromatographies and purified by preparative HPLC. The chemical structures had been identified by physiochemical properties and spectroscopic methods. Results Six caffeoylquinic acid derivatives were identified as 3, 5-di-O-caffeoylquinic acid ( Ⅰ ),3, 4-di-O-caffeoylquinic acid ( Ⅱ ), 4, 5-di-O-caffeoylquinic acid ( Ⅲ ), 4-O-caffeoylquinic acid ( Ⅳ ), 5-O-caffeoylquinic acid ( Ⅴ ), 4-[3-(3, 4-dihydroxy-phenyl)-acryloyloxy]-2, 3-dihydroxy-2-methyl-butyric acid ( Ⅵ ). Conclusion Compounds Ⅰ - Ⅵ are first obtained from B. parviflora and Ⅵ is new one. Some of the compounds exhibit the activities in antiallergic assays. Moreover, the structure-activity relationships of these compounds have been also discussed in this paper.
