Effects of Psoralen on Improving Chemotherapeutics Drug's Concentration of HL60 Cells
- VernacularTitle:补骨脂素对HL60耐药细胞内化疗药物浓度影响研究
- Author:
Yu CAI
;
Shaolei YU
- Publication Type:Journal Article
- Keywords:
psoralen;
reverse;
multidrug resistance;
HL60/HT cell
- From:Space Medicine & Medical Engineering
2006;19(6):391-393
- CountryChina
- Language:Chinese
-
Abstract:
Objective To determine the reversal effect of psoralen on multidrug resistance (MDR) in the harringtonine (HT)-resistant leukemic cell line HL60/HT. Method The modulating effect of psoralen on MDR in HL60 and HL60/HT cells were determined by the measurement of cell growth and viability via MTT assay. High performance liquid chromatography(HPLC) was used to analyze intracellular HT concentrations in HL60/HT and HL60 cells treated with psoralen. Result Psoralen from 1 to 20 μmol/L could reduce the value of IC50 to HT and enhance the accumulation of HT in HL60/HT cells. Conclusion Psoralen can reverse MDR of HL60/HT cells and is a potential modulator of MDR.
