A simple and repeatable orthotopic model of the A549 cell line in nude mice
- VernacularTitle:一种简单可靠的A549裸小鼠原位接种模型的建立
- Author:
Kai KANG
;
Bingliang MA
- Publication Type:Journal Article
- From:
Chinese Journal of Clinical Pharmacology and Therapeutics
2006;11(10):1102-1105
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To establish a simple and repeatable orthotopic animal model of the A549 cell line.METHODS: A549 cells in matrigel were inoculated into left lung or right flank of nude mouse. The growth pattern of A549 tumors and the chemotherapeutic efficacy of carboplatinum were studied. RESULTS: Tumors generated and dispersed widespreadly to contralateral lung. Tumors in lung were less susceptible to carboplatinum than those growing in flank. CONCLUSION: A simple and repeatable orthotopic animal model of the A549 cell line was presented, this allows researchers to evaluate novel compounds and new drugs for treatment of human lung cancer.KEY WORDS A549 cell line; orthotopic model; nude mice
