Progress on the relationship of pancreatic cells development and function and intrauterine growth retardation
10.3760/cma.j.issn.1673-4408.2011.02.009
- VernacularTitle:宫内发育迟缓对胰腺β细胞发育和功能影响机制的研究进展
- Author:
Yao LI
- Publication Type:Journal Article
- Keywords:
Intrauterine growth retardation;
Pancreatic;
Animal model;
Insulin resistance
- From:
International Journal of Pediatrics
2011;38(2):124-126
- CountryChina
- Language:Chinese
-
Abstract:
Intrauterine growth retardation (IUGR) can improve the danger of insulin resistance syndrome. It was reported that regulatory factors of βcells development and enzymes of regulating metabolism of glucose, fat, insulin signal transduction and effecter molecule were expressed at a low level in the IUGR. As a result, the number of β cells, proliferation, insulin secretion and insulin sensitivity was reduced, apoptosis was increased, and glucose intake in peripheral tissue declined. All these factors contribute to the insulin resistance syndrome.
