Clinical effect in treatment of Alzheimer disease based on the conditions of heart and kidney
- VernacularTitle:从心肾论治阿尔茨海默病的临床效果
- Author:
Shuimiao LIN
;
Jian WANG
;
Ruqian ZHOU
;
Zhihua YU
- Publication Type:Journal Article
- From:
Chinese Journal of Tissue Engineering Research
2006;10(11):162-164
- CountryChina
- Language:Chinese
-
Abstract:
BACKGROUND: Clinically Alzheimer disease (AD) is characterized by obscurity in onset, decline of intelligence, and dysfunctions of behavior and nerve system. The essence of AD is impairment of memory and cognition.OBJECTIVE: To explore the effective mechanism of tiaoxin recipe (TXR)and bushen recipe (BSR) in treating AD.DESIGN: Randomized controlled study.SETTING: Shanghai Institute of Traditional Chinese Medicine for Geriatrics.PARTICIPANTS: Totally 60 AD patients were selected from Shanghai Institute of Traditional Chinese Medicine for Geriatrics from October 1999to January 2000.METHODS: Sixty patients with AD were divided into 3 groups, with 20in each group. The patients in TXR and BSR group took respectively TXR and BSR 10 mL once, 2 times per day. The patients in donepezil (Dp)group took a Dp capsule once a day, h.s (Dp was produced in England Boots Company, 5 mg per capsule). For a course consisted of 12 weeks.The changes of Mini mental state examination (MMSE) score, Activity of Daily Living Scale (ADL) score, neuropsychological testing (NPT) score,including FULD object-memory evaluation (FOM), rapid verbal retrieval (RVR), digit span test (DS) and block design (BD), as well as the overall operational evaluation before and after treatment were analyzed.MAIN OUTCOME MEASURES: Scores of MMSE, ADL, NPT and the overall operational evaluation.RESULTS: Totally 60 patients entered the final analysis. ① MMSE scores in the 3 groups were decreased after treatment as compared with those before treatment (P ＜ 0.01). Total effective rates were 70%, 65% and 75% respectively (P ＞ 0.05). ② ADL scores in the 3 groups were decreased after treatment as compared with those before treatment (P ＜ 0.05or P ＜ 0.01). Total effective rates were 45%, 45% and 40% respectively (P ＞ 0.05). ③ Total effective rates were 70%, 65% and 75% respectively (P ＞ 0.05). ④ Scores of FOM were increased in the TXR and the Dp group after treatment as compared with those before treatment (P ＜ 0.05). RVR scores in the three groups were increased after treatment as compared with tbose before treatment (P ＜ 0.05); DS scores were increased in TXR group and Dp group after treatment as compared with those before treatment (P ＜ 0.05 or P ＜ 0.01); and BD scores in BSR group were increased after treatment as compared with those before treatment (P ＜ 0.05).CONCLUTION: TXR, BSR and Dp can improve cognitive function and daily living ability of AD patients, and TXR and BSR are effective TCM drugs in treating AD.
