Characteristics of sleep-wake cycles in mice lacking prostanoid DP receptors
- VernacularTitle:前列腺素DP受体缺乏小鼠的睡眠-觉醒特征
- Author:
Zhangqing MA
;
Zongyuan HONG
- Publication Type:Journal Article
- Keywords:
prostaglandin D2;
DP receptor;
sleep-wake cycle;
rapid eye movement sleep;
non-rapid eye movement sleep;
mice
- From:
Chinese Journal of Clinical Pharmacology and Therapeutics
2006;11(11):1296-1300
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To investigate the effect of prostanoid DP receptors (DPR) on sleep-wake regulation in mice. METHODS: Under pentobarbital anesthesia, mice were chronically implanted with electroencephalogram (EEG) and electromyogram (EMG) electrodes for polysomnographic recordings. The spontaneous sleep-wake cycles were monitored continuously by EEG/EMG recording system for 24 h beginning at 800 p.m. and analyzed by SLEEPSIGN software in DPR knock out (KO) and wild type (WT) mice. RESULTS: DPR-KO mice exhibited a similar circadian rhythm of sleep-wake cycles to WT mice. The amounts of rapid eye movement (REM) sleep or non-REM (NREM) sleep during both the light and dark periods were identical between the DPR-KO and WT mice. Whereas, an increase in the episode number of wakefulness and a shortage in the duration of NREM sleep were found in DPR-KO mice during the light period compared with WT mice. Moreover, DPR-KO mice showed lower activity in delta-wave component in NREM sleep and higher activity in theta-wave component in REM sleep than WT mice. CONCLUSION: DPR plays a crucial role in mediating the prostaglandin D2-induced sleep. Deficiency of DPR results in the low intensity and fragmented diurnal NREM sleep and the high vigilance REM sleep, with the normal circadian rhythm of sleep in mice.
