Terbinafine versus itraconazole for treatment of dermatophyte onychomycosis: a meta-analysis
- VernacularTitle:特比萘芬与伊曲康唑治疗甲癣疗效的Meta分析
- Author:
Jing SHI
;
Jianjun QIAO
;
Ming XIE
- Publication Type:Journal Article
- Keywords:
onychomycosis;
arthrodermataceae;
terbinafine;
itraconazole;
meta-analysis
- From:
Chinese Journal of New Drugs and Clinical Remedies
2006;25(11):809-812
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To access the difference of the efficacy between terbinafine and itraconazole in the treatment of dermatophyte onychomycosis. METHODS: The Medline, Science Direct On Site (SDOS), and Springer database were searched in detail on the data of the mycological cure rates of the two antifungal agents for treatment of dermaphyte onychomycosis occourring in patients aged from 18 a to 60 a with the published double blind randomized clinical trials and then pooled. The odds ratio (OR) and its 95 % confidence interval (CI) were calculated. RESULTS: Six treatises of double blind randomized clinical trials were selected for this analysis according to the screening criteria. The mycological cure rate of continuous terbinafine 250 mg per day was higher than that of either therapeutic effect of itraconazole pulse 400 mg per day (OR = 5.01, 95 % CI (3.42 - 7.33)) or continuous itraconazole 200 mg per day (OR = 2.58, 95 % CI (1.91 - 3.49)) . CONCLUSION: Terbinafine is more effective than itraconazole in the treatment of dermatophyte onychomycosis.
