Prostate Cancer Bone Metastasis: Interaction Between Tumor Cells and Bone Microenvironment
- VernacularTitle:前列腺癌骨转移:肿瘤细胞与骨微环境之间的相互作用
- Author:
Yi LU
;
Zhi YAO
;
Jian ZHANG
- Publication Type:Journal Article
- Keywords:
cytokines;
chemokines;
chemokine receptors;
cancer;
bone metastasis
- From:
Chinese Journal of Biochemistry and Molecular Biology
2007;23(3):1-171
- CountryChina
- Language:Chinese
-
Abstract:
Cancer metastasis is composed of a complex cascade that involves a variety of critical steps beginning with detachment from the primary tumor and ending with growth of tumor at a distant site, such as bone. The "seed-and-soil hypothesis" predicts that the bone microenvironment expresses factors through which attract a variety of cancer cells and promote the tumor development. The ending point of tumor development in bone is achieved through the bidirectional and dynamic interaction between tumor cells and the cells in their growth microenvironment. A variety of factors produced by the bone microenvironment, contribute to the pathogenesis of cancer skeletal metastasis. In this review, using prostate cancer (CaP) as an example, some of general mechanisms of cancer metastasis will be summarized. In addition, the current understanding of the interaction between tumor cells and the bone microenvironment will be addressed. Finally, the research directions in the near future will be suggested.
