Inhibition of matrine on potassium currents in guinea pig ventricular myocytes
- VernacularTitle:苦参碱对豚鼠心肌细胞钾电流的抑制作用
- Author:
Yuhong ZHOU
;
Chaoqian XU
;
Hongli SHAN
;
Yanjie Lü
;
Baofeng YANG
- Publication Type:Journal Article
- Keywords:
matrine;
myocardium;
potassium channels;
patch clamp techniques,whole-cell
- From:
Chinese Journal of Pharmacology and Toxicology
2007;21(3):167-173
- CountryChina
- Language:Chinese
-
Abstract:
AIM To elucidate the possible antiarrhythmic mechanism of matrine. METHODS Whole-cell patch-clamp technique was used to record ionic currents in ventricular myocytes. RESULTS In guinea pig ventricular myocytes, matrine 100 μmol·L-1 prolonged 90% action potential duration (APD90) by 40% at a stimulation of 0.1 Hz in a frequency-independent manner, inhibited IK1 by 47% at the test potential of -120 mV, reduced IKr,tail by 50% and had no effect on IKs,tail. CONCLUSION Matrine prolonged APD through blockade of multiple potassium currents, which may relate to its antiarrhythmic efficacy.
