Resveratrol inhibits carotid sinus baroreceptor reflex in anesthetized rats
- VernacularTitle:白藜芦醇抑制麻醉大鼠颈动脉窦压力感受性反射
- Author:
Hongmei XUE
;
Yuming WU
;
Lin XIAO
;
Ru WANG
;
Fuwei WANG
;
Ruirong HE
- Publication Type:Journal Article
- Keywords:
resveratrol;
carotid sinus;
pressoreceptors
- From:
Chinese Journal of Pharmacology and Toxicology
2007;21(3):161-166
- CountryChina
- Language:Chinese
-
Abstract:
AIM To study the relationship between cardioprotective effects of resveratrol and carotid sinus baroreflex (CSB). METHODS The functional curve of the CSB was measured by recording changes in arterial pressure in anesthetized male rats with perfused isolated carotid sinus. RESULTS Resveratrol (30, 60 and 120 μmol·L-1) inhibited the CSB, which shifted the functional curve of the baroreflex to the right and upward. There were a marked decrease in peak slope and a reflex decrease of blood pressure, and also an increase in threshold pressure. Changes of these parameters showed a concentration-dependent manner. Pretreatment with Nω-nitro-L-arginine methylester (100 μmol·L-1), an inhibitor of nitric oxide synthase, and pretreatment with Bay K8644 (500 nmol·L-1), an agonist of L-type calcium channel, could both eliminate the inhibitory effect of resveratrol on CSB. A potent inhibitor of tyrosine phosphatase sodium orthovanadate (1 mmol·L-1) did not influence the effect of resveratrol on CSB. CONCLUSION Resveratrol inhibits carotid baroreflex, which may be mediated by the locally released NO and decreased calcium influx.
