Analysis of T Cell Clonality in Patients with Systemic Lupus Erythematosus
- VernacularTitle:系统性红斑狼疮患者T细胞克隆性的分析
- Author:
Hongqing CHEN
;
Wenyan XU
- Publication Type:Journal Article
- From:
Chinese Journal of Dermatology
2001;34(1):15-17
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the T cell clonality in patients with systemic lupus erythematosus (SLE) . Methods T cell clonality in peripheral blood lymphocytes from six patients with active SLE was analyzed using reverse transcriptase- polymerase chain reaction (RT- PCR) and GeneScan technique. Results T cell receptor (TCR) Vβ PCR products from two patients were derived from polyclonal T cells, however, TCR Vβ9, Vβ2, VβI, Vβ2 pioducts from the other four patients were derived from oligoclonal T cells respectively.ConclusionT cells from patients with SLE demonstrated a striking oligoclnality and their clonal expansion may be a specific response driven by autoantigens.
