Recent progress in the improvement of the coupling efficiency of "difficult sequences" in peptide synthesis
- VernacularTitle:多肽合成中"困难序列"的缩合研究进展
- Author:
Xiang HAN
;
Dexin WANG
- Publication Type:Journal Article
- Keywords:
peptide synthesis;
coupling efficiency;
difficult sequences;
β-structure of peptide
- From:
Acta Pharmaceutica Sinica
2007;42(2):111-117
- CountryChina
- Language:Chinese
-
Abstract:
Even though chemistry is now in place that potentially allows high coupling efficiencies to be attained, successful coupling is usually a challenge when so-called "difficult sequences" is encountered in peptide synthesis. Some factors that affect the coupling efficiency have been discussed and related methods to overcome those obstacles have been introduced in present review. All suggestions proposed here are valuable and also feasible to improve the coupling completeness in both liquid-phase or solid-phase peptide synthesis.
