Diterpenes from Helianthus annuus and their cytotoxicity in vitro
- VernacularTitle:向日葵二萜化学成分及其细胞毒活性研究
- Author:
Maorong SUO
;
Ze TIAN
;
Junshan YANG
;
Yang Lü
;
Li WU
- Publication Type:Journal Article
- Keywords:
Helianthus annuus;
diterpene;
cytotoxicity
- From:
Acta Pharmaceutica Sinica
2007;42(2):166-170
- CountryChina
- Language:Chinese
-
Abstract:
To search for bioactive compounds from the flower disc of Helianthus annuus L.,chromatography was used to isolate and purify the chemical constituents, their structures were identified by spectral analysis, MTT method was applied to investigate their cytotoxic activities, some compounds showed moderate cytotoxic activities on SF-268, MCF-7 and HepG2 cell lines. Eleven compounds were obtained from the flower disc of H. annuus, and identified as ent-kaurane-2o, 16α-diol ( 1 ) and entkaurane-15α, 16α-epoxy-17-al-19-oic acid (2), and nine known diterpenes, ent-kaurane-16β-ol (3),phyllocladan-16β-ol (4) , ent-atisan-16α-ol ( 5 ) , grandifloric acid ( 6 ) , angeloylgrandifloric acid ( 7 ) ,ent-kaurane-16-en-19-oic acid (8), ent-kaurane-17-hydroxy-15-en-19-oic acid (9), ent-kaurane-16β,17-dihydroxy-19-oic acid (10), and ciliaric acid (11). Compounds 1 and 2 are new compounds, some compounds showed cytotoxic activities on SF-268, MCF-7 and HepG2 cell lines.
