Development of Therapy for Duchenne Muscular Dystrophy
- VernacularTitle:杜兴肌营养不良症治疗进展及前景
- Author:
Suzhen ZHANG
;
Huiqi XIE
;
Guangqian ZHOU
;
Zhiming YANG
- Publication Type:Journal Article
- Keywords:
Dystrophin gene;
Muscular dystrophy;
Gene therapy;
Cell therapy;
Pharmacological therapy
- From:
Chinese Journal of Reparative and Reconstructive Surgery
2007;21(2):194-203
- CountryChina
- Language:Chinese
-
Abstract:
Objective To review and summarize the latest development of the therapy for the Duchenne muscular dystrophy (DMD). Methods The recently-published articles related to the therapies for DMD were extensively reviewed and briefly summarized. Results The therapeutic approaches for DMD included the gene therapy, the cell therapy, and the pharmacological therapy.The gene therapy and the cell therapy were focused on the treatment for the cause of DMD by the delivery of the missing gene, the modification of the mutated gene, and the transfer of the normal cells including the stem cells, while the pharmacological therapy dealt with the downstream events caused by the dystrophin gene defect, slowed down the pathologic progress of DMD, and improved the DMD patient's life quality and life span, by medication and other factor treatments. Conclusion There is still no cure for DMD because of various difficulties in replacing or repairing the defected gene and of the multifaceted nature of the severe symptoms. Therefore, it is imperative for us to find out a more effective treatment that can solve these problems.
