Experimental study on anti-inflammation and analgesia effect and acute toxicity of extract from Pongamia pinnata roots
- VernacularTitle:水黄皮根乙醇提取物的抗炎镇痛作用及其急性毒性的实验研究
- Author:
Keyun LIU
;
Yi ZHU
;
Zhi DONG
;
Guobiao CHENG
;
Yumei ZHAO
;
Bei LI
;
Chun LIU
;
Jin LI
- Publication Type:Journal Article
- Keywords:
Pongamia pinnata root;
anti-inflammation;
analgesia;
acute toxicity
- From:
Chinese Traditional Patent Medicine
2007;29(2):179-183
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To study the effect of extract from Pongamia pinnata roots on anti-inflammation and analgesia and acute toxicity. METHODS: The models of mice ear edema induced by xylene and Cotton pellet granuloma in rats to observe the anti-inflammation effect of PRE via oral administration. The effect of PRE on analgesia was tested by measuring the latent period licking hind foot with the hot plate method and counting body twisting induced by acetic acid in mice. The acute toxicity of PRE was measured by the method of Bliss. RESULTS: PRE could significantly inhibit the ear edema caused by xylene in mice, granuloma hyperplasia caused by cotton in rats. It could significantly prolong the pain threshold on hot-plate in mice, reduce the writhing times in mice. The LD50 of PRE was 6. 371 8 g/kg, its 95% confident limit was 5. 408 4-7. 723 2 g/kg. CONCLUSION: PRE has obvious effect on anti-inflammation and analgesia and the lower acute toxicity.
