Terpenoids and flavonoids from Laggera pterodonta
- VernacularTitle:臭灵丹萜类和黄酮化合物
- Author:
Guangzhong YANG
;
Yunfang LI
;
Xin YU
;
Zhinan MEI
- Publication Type:Journal Article
- Keywords:
Laggera pterodonta;
monoterpene glucoside;
terpenoids;
flavonoids;
antibacterial activity
- From:
Acta Pharmaceutica Sinica
2007;42(5):511-515
- CountryChina
- Language:Chinese
-
Abstract:
To study the chemical constituents of aerial parts of Laggera pterodonta (DC.) Benth., the air-dried aerial parts of this plant were powered and extracted with boiling water and purified by silica gel column chromatography and recrystallized. Eleven compounds were obtained from L.pterodonta. They were identified as to be 6-O-β-D-glucopyranosyl-carvotanacetone (1), pterodontic acid (2), 1β-hydroxy pterondontic acid (3), pterodontoside A (4), pterodondiol (5), pterodontriol B (6), 5-hydroxy-3,4′,6,7-tetramethoxyflavone (7), artemitin (8), chrysosplenetin B (9), quercetin (10) and β-sitosterol (11). Compound 1 is a new monoterpene glucoside. Compounds 10 and 11 were isolated from this plant for the first time. Compounds 2 and 5 showed moderate activity against bacteria including Staphylococcus aureus, Pseudomonas aeruginosa, Bacillus subtilis, Mycobacteium phlei and Bacillus circulans by paper disc diffusion method, while they both displayed no activity against Escherichia coli.
