Microenvironment of primary liver cancer and regulatory T cells
10.3760/cma.j.issn.1673-422X.2011.01.018
- VernacularTitle:肝癌微环境与调节性T细胞
- Author:
Juan HU
;
Shubing ZOU
;
Fan ZHOU
- Publication Type:Journal Article
- Keywords:
Liver neoplasms;
Antigens,differentiation,T-lymphocyte;
Neoplasms microenvironment;
T-lymphocytes regulatory
- From:
Journal of International Oncology
2011;38(1):54-56
- CountryChina
- Language:Chinese
-
Abstract:
Regulatory T cell (Treg) infiltration is an important mechanism for inhibition of tumor immune microenvironment. Treg is highly expressed in peripheral blood and tumor tissue of various cancer patients. A high expression of Treg may inhibit the antitumor effect of CD4 + CD8 + T lymphocytes or induce immunological resistance to tumor antigens among cytotoxic T lymphocytes(CTL) without producing acute or memory CTL responses, resulting in tumor escape from immuneattack and immune suppressionin in the tumor microenvironment.
