Research and progress in tissue-engineered skin
- VernacularTitle:组织工程皮肤的研究与进展
- Author:
Junyi ZHANG
;
Chunmei WANG
- Publication Type:Journal Article
- From:
Chinese Journal of Tissue Engineering Research
2007;11(10):1988-1991
- CountryChina
- Language:Chinese
-
Abstract:
BACKGROUND:Tissue-engineered skin is a new method to cure the massive defects of skin caused by burn or trauma.Therefore, the seed cells and scaffold on the tissue-engineered skin have become the focus today.DATA SOURCES: A computer-based online search of Pubmed database was undertaken to identify the articles about tissue-engineered skin published in English between January 1990 and January 2007 with the key words of "tissue engineered skin, stem cell". Meanwhile, we searched Chinese Journals Full-text Database for related Chinese articles published between January 1994 and January 2007 with the key words of index "tissue engineered skin, skin stem cell" in Chinese.STUDY SELECTION: The data were selected firstly to choose the full-text of articles met the criteria. Inclusive criteria:① Articles about seed cells of tissue engineered skin;②Articles about the scaffold of tissue-engineered skin. Exclusive criteria: Repetitive or analogical articles, Meta analysis or case reports.DATA EXTRACTION: Totally 97 articles on tissue-engineered skin were collected and 69 met the inclusive criteria after eliminated the repetitive or similar studies.DATA SYNTHESIS: The development of tissue engineering provides a new approach for the treatment of massive defects with skin transplantation, and gets rid of some problems such as donor site shortage, immune rejection, disease spread et al.① Skin seed cell: Embryonic stem cell and various adult stem cells can serve as seed cell of tissue-engineered skin, and embryonic stem cell is the first choice, which is transplanted on the biological scaffold to acquire the epidermis, dermis and compound skin.②Research progress of epidermis substitute.③Methods to make dermal substitute.④Research direction of compound artificial skin.⑤There are many problems in wide clinical application of tissue-engineered skin, but more and more attention has been paid on its research.CONCLUSION: Tissue-engineered skin is the best choice to cure the massive defects of skin and has a wide clinical prospect. With the rapid development of life science, operation technology, material science and many other related subjects, the ideal tissue-engineered skin can be obtained with similar function and feature to natural skin.
