Changes and clinical significance of peripheral blood interferon-γ,interleukin-4 and interleukin-6 in endometriosis

VernacularTitle:子宫内膜异位症患者外周血干扰素γ、白细胞介素4和白细胞介素6的变化及其临床意义
Author: Ting ZHANG ; Fang LIAN
Publication Type:Journal Article
Keywords: Endometriosis; Interferon-gamma; Interleukin-4; Interleukin-6
From: Chinese Journal of Postgraduates of Medicine 2011;34(12):18-19
CountryChina
Language:Chinese
Abstract: Objective To study the changes of interferon ( IFN )- γ ,interleukin(IL)-4 and IL-6 in endometriosis. Method The levels of peripheral blood IFN-γ ,IL-4 and IL-6 in 25 patients with endometriosis (EM group) and 20 normal adults (control group) were detected by enzyme linked immunosorbent assay (ELISA). Results The level of peripheral blood IFN- γ in EM group [(109.64±26.79 ) ng/L] was lower than that in control group [(155.17±30.36) ng/L] (P ＜ 0.05 ), IL-4[(33.52 ± 8.69)ng/L]and IL-6 [(44.12 ± 3.57) ng/L] were higher than those in control group [(22.52 ± 6.54), ( 15.12 ±2.63 )ng/L](P＜0.05 ).The ratio of IFN-γ/II-4(3.27±1.45 ) and IFN- γ/IL-6 ( 1.15 ± 0.56 ) in EM group were significantly lower than those in control group (6.89 ±1.68,2.54 ±1.03)(P ＜0.01 or ＜0.05).Conclusions Th1 cells shift toward Th2 cells in patients with endometriosis. Th1/Th2 ratio may be correlated with the pathogenesis of endometriosis.