Genetic polymorphisms of human β-adrenergic receptor genes and their association with obesity
- VernacularTitle:人类β-肾上腺素受体基因的遗传多态性及其与肥胖的关系
- Author:
Zhaoqian LIU
;
Wei MO
;
Qiong HUANG
;
Honghao ZHOU
- Publication Type:Journal Article
- Keywords:
β-adrenergic receptor;
single nucleotide polymorphism;
haplotype;
lipolysis;
obesity
- From:
Journal of Central South University(Medical Sciences)
2007;32(3):359-367
- CountryChina
- Language:Chinese
-
Abstract:
The prevalent rates of overweight and obesity are steadily increasing all over the world. Previous studies of some candidate genes have indicated that most of the genes are associated with obesity in human adipose tissue. As much as 40% of the variations in body mass could be attributed to genetic difference. The β-adrenergic receptor (β-AR) plays a major role in the regulation of energy balance in humans. A high sympathetic nervous system activity has been shown to be associated with obesity and is believed to have pathogenetic relevance. Several common single nucleotide polymorphisms (SNPs) including Gly389Arg in β1-AR, Gln27Glu in β2-AR, and Trp64Arg in β3-AR in humans could alter receptor function and these variations ofβ-ARs were shown to have certain association with obesity. Here we summarize the genetic polymorphisms of human β-ARs and their potential impacts to obesity.
