A Case of Primary Extragastrointestinal Stromal Tumor Presenting as Peritoneal Dissemination.
10.4166/kjg.2010.56.5.319
- Author:
Hong Jun YANG
1
;
Tae Ho KIM
;
Min Kyoung PARK
;
Chang Hoon LIM
;
Kee Hyun LEE
;
Chang Whan KIM
;
Sok Won HAN
;
Jean A KIM
Author Information
1. Department of Internal Medicine, The Catholic University of Korea College of Medicine, Seoul, Korea. drkimtaeho@yahoo.co.kr
- Publication Type:Case Report ; English Abstract
- Keywords:
Gastrointestinal stromal tumor;
Extragastrointestinal stromal tumor;
Peritoneum
- MeSH:
Actins/metabolism;
Aged;
Antigens, CD34/metabolism;
Gastrointestinal Stromal Tumors/*diagnosis/pathology;
Humans;
Laparoscopy;
Male;
Peritoneal Neoplasms/*diagnosis/secondary;
Positron-Emission Tomography;
Proto-Oncogene Proteins c-kit/metabolism;
Tomography, X-Ray Computed;
Vimentin/metabolism
- From:The Korean Journal of Gastroenterology
2010;56(5):319-323
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Gastrointestinal stromal tumor (GIST) is the most common mesenchymal tumor of the gastrointestinal tract, but also occurs at a lower frequency in extra-gastrointestinal regions such as omentum, mesentery, retroperitoneum and undefined abdominal sites. This tumor is called extragastrointestinal stromal tumor (EGIST). EGIST is mostly diagnosed as a cystic mass, but rarely occurs as a disseminated abdominal tumor. We experienced a 70-year-old man with primary EGIST presenting as peritoneal dissemination. Abdominal CT showed diffuse peritoneal thickening with a large amount of ascites, but no definite mass lesion. Laparoscopic biopsy was performed and histologic findings showed tumor composed of epithelioid cells. In the results of immunohistochemical stains, the tumor showed positive reactivity with CD117 (c-kit), CD34, vimentin and actin, but negative reactivity with desmin and S-100 protein. On account of unresectability and histologic parameters of malignant behavior, he was started on imatinib.
