Effects of Shuguan Capsule on myocardial blood flow and myocardial oxygen consumption in dogs
- VernacularTitle:疏冠胶囊对犬心肌血流量和心肌耗氧量的影响
- Author:
Jianxun LIU
;
Xinzhi LI
;
Xiaohong SHANG
;
Jianhua FU
;
Weihong CONG
- Publication Type:Journal Article
- Keywords:
Shuguan Capsule (Corocalm);
myocardial blood flow;
myocardial oxygen consumption;
mongrel dog
- From:
Chinese Traditional Patent Medicine
2007;29(8):1115-1119
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To investigate the effects of Shuguan Capsule on myocardial blood flow (MBF) and myocardial oxygen consumption (MOC) in anesthetized dogs. METHODS: Coronary blood flow (CBF) of twenty-five thoracotomized dogs was detected by electromagnetic flow meter and the MBF was calculated. While the oxygen content in the artery (AO2 ) and in the coronary venous sinus (VO2) was determined with blood oxygen analysis.Moreover, the other cardiac hemodynamic parameters, such as heart rate (HR), femoral arterial blood pressure (BP), were observed by physiological polygraph. RESULTS: It was found that Shuguan Capsule (48.5 mg/kg and 194 mg/kg) could significantly increase the MBF, and then decease the coronary artery resistance. Furthermore, Shuguan Capsule could also lower the AO2, but increase the VO2, which led to the decreased MOC. CONCLUSION: Shuguan Capsule exhibits the effects to keep the balance between blood supply and oxygen consumption in the heart by modulating the coronary resistance and by reducing MOC in dogs.
