Relationship between Polymorphism of Pulmonary Surfactant Protein A Gene and Adaptation to Hypobaric Hypoxia
- VernacularTitle:肺表面活性物质相关蛋白A基因多态性与高原低氧适应性关系
- Author:
Shengwei WANG
;
Xuechuan SUN
;
Kunxiang LIU
- Publication Type:Journal Article
- Keywords:
surfactant proteins;
single-nucleotide polymorphisms;
hypoxia;
adaptation
- From:Space Medicine & Medical Engineering
2007;20(4):235-239
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the relation between polymorphisms of pulmonary surfactant protein A gene and adaptation to hypobaric hypoxia. Methods The genotype proportions and allel frequencies of 86 Tibetan mountaineers and 90 sea-level Hans were examined with polymerase chain reaction-sequence specific primer(SSP-PCR) reaction for surfactant protein A gene. Results The constituent ratio of A/A,A/G and G/G genotypes in A1-aa62 locus and C/C,A/C and A/A genotypes in A2-aa223 locus showed significant statistic difference between highland group and the sea-level control group(P＜0.05). A1-aa62 G/G and A2-aa223 A/C genotype demonstrated high odds ratio in Tibetan mountaineers. Moreover, the comparisons of genotypes and alleles in A1-219 locus showed no significant difference between the plateau group and the sea-level Han control(P＞0.05). Conclusion The single-nucleotide polymorphisms(SPN) in SP-A1aa62 and SP-A2aa223 may be associated with the adaptation to hypobaric hypoxia.
