Study on absorption and distribution of oxybutynin oral tablet and transdermal gel in rats
- VernacularTitle:大鼠奥昔布宁片剂口服给药与凝胶剂经皮给药吸收与组织分布研究
- Author:
Qing WEN
;
Kun FENG
;
Ruichen GUO
- Publication Type:Journal Article
- Keywords:
oxybutynin;
transdermal gel;
pharmacokinetics;
HPLC-MS;
rats
- From:
Chinese Journal of Clinical Pharmacology and Therapeutics
2006;11(5):586-589
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To study the absorption and distribution characteristics of oxybutynin (OXY) oral tablet and transdermal gel. METHODS: A single dose of 0.1 g OXY transdermal gel (2 mg OXY) was applied to abdominal area about 4 cm2 and 0.5 mg immediate-release tablet was orally given to 48 rats in a randomized, open-label, control design test. The plasma, bladder and liver tissue were collected, disposed and analyzed and OXY pharmacokinetic parameters were calculated and evaluated. RESULTS: The Cmax of OXY transdermal gel and oral tablets in bladder are approximately 800 and 70 times higher than those in plasma. The plasma half life of OXY gel delayed 5.99 h, tablets 2.18 h. CONCLUSION: OXY gel show better pharmacokinetic properties, characterized with long half life and high target organ concentrations than those of tablets.
