Pharmacokinetics and bioavailability of two kinds of zidovudine capsules in Chinese healthy volunteers
- VernacularTitle:两种齐多夫定胶囊在健康人体的药动学和生物利用度比较(英文)
- Author:
Xin TIAN
;
Hailing QIAO
;
Yuzhong GUO
;
Na GAO
;
Linjing JIA
;
Lirong ZHANG
- Publication Type:Journal Article
- Keywords:
zidovudine;
chromatography,high pressure liquid;
pharmacokinetics;
biological availability;
bioequivalence
- From:
Chinese Journal of New Drugs and Clinical Remedies
2006;25(5):321-325
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To develop a simple and sensitive high-performance liquid chromatography (HPLC) for the quantification of zidovudine and to study the pharmacokinetics of two kinds of zidovudine capsules in Chinese healthy volunteers. METHODS :The concentrations of zidovudine in plasma were determined by a validated HPLC method with UV detection. A randomized two-way crossover study was conducted in 18 fasting volunteers to compare plasma pharmacokinetic profile and single-dose tolerability of a new zidovudine capsules. RESULTS: The main pharmacokinetic parameters of two formulations, reference and test capsules, were as follows: cmax were (2 252±s 837) μg·L-1 and (2 300±1 099) μg·L-1; tmax were (0.49±0.19) h and (0.5±0.3) h;t1/2 ke were (0.93±0.19) h and (0.99±0.24) h; AUC0-t were (2 530±452) μg·h·L-1 and (2 467±605) μg·h·L-1;AUC0-∞ were(2 689 ± 414) μg·h·L-1 and (2 583±575) μg·h·L-1. The results of ANOVA and two one-side t test statistical analysis for lg AUC0-t, lg AUC0-∞ and lg cmax showed that two formulations were bioequivalent. CONCLUSION:The method is convenient, sensitive, accurate and reproducible, and could be applied to determining the plasma zidovudine concentration and studying on pharmacokinetics. Two zidovudine capsules are bioequivalent in Chinese healthy volunteers.
