Progress about the relationship between platelet-derived growth factor and proliferation of mesangial cells
10.3760/cma.j.issn.1673-4408.2011.02.016
- VernacularTitle:血小板源性生长因子与系膜细胞增殖研究进展
- Author:
Jun ZHENG
- Publication Type:Journal Article
- Keywords:
Platelet-derived growth factor;
Proliferation of mesangial cell;
Antagonist;
Inhibitor
- From:
International Journal of Pediatrics
2011;38(2):144-146
- CountryChina
- Language:Chinese
-
Abstract:
Platelet-derived growth factor(PDGF), as an important cytokine, can induce mesangial cell proliferation and accumulate extracellular matrix. The proliferation of the mesangial cells correlate with the cell cycle regulation. The different isoform of PDGF works on mesangial cells to produce different effects. This review summarizes the relevant mechanism about PDGF inducing proliferation of mesangial cells.
