Pharmacokinetic interaction between cefaclor and bromhexine in healthy Chinese volunteers
- VernacularTitle:头孢克洛与溴己新在中国健康人体内药动学环节的相互作用
- Author:
Qian GONG
;
Zheyi HU
;
Zhizhuang HUANG
;
Liqing WANG
;
Wenfang LIU
;
Xin GUO
;
Wei CAO
;
Ting WANG
;
Zeneng CHENG
- Publication Type:Journal Article
- Keywords:
cefaclor;
bromhexine;
drug-drug interaction;
HPLC;
LC-MS
- From:
Journal of Central South University(Medical Sciences)
2007;32(5):855-861
- CountryChina
- Language:Chinese
-
Abstract:
Objective To determine the pharmacokinetic interaction between cefalor and bromhexine in healthy Chinese volunteers. Methods Twelve subjects received a cefaclor (CEF) treatment, a bromhexine (BHX) treatment, and a co-treatment of CEF and BHX with a 3 × 3 Latin square design. The wash-out time between periods was 14 days. The plasma and urine drug concentrations of CEF and BHX were detected by HPLC-UV and LC/MS, respectively. Results All the 12 volunteers completed the study. There were no significant differences in AUC0-t and Cmax of CEF in logarithm between the single administration group of CEF and the co-administration group of CEF with BHX. Two one sided t-test showed that CEF was bioequivalent in the 2 groups. There were no significant differences in tmax, MRT, t1/2, and Clr between the 2 groups. Vd/F was significantly lower in the single CEF group than in the co-administration group of CEF and BHX. There were no significant differences of AUC0-t and Cmax of BHX in logarithm between the single administration group of BHX and the co-administration group of BHX with CEF. Two one sided t-test showed that BHX was bioequivalent in the 2 groups. There were no significant differences in tmax, MRT, t1/2, Vd/F, and Clr between the 2 groups. Conclusion There is no significant pharmacokinetic parameter change in the drug absorption, metabolism, and excretion, but Va/F of CEF significant increases in the co-administration of CEF with BHX. The co-administration of CEF and BHX has no adverse drug interaction. The increase of Vd/F may be a favorable drug interaction, which may be the mechanism of the synergistic effect of the 2 drugs.
