Characteristics of ventricular electrophysiology in a right ventricular rapid pacing-induced canine heart failure model
- VernacularTitle:右心室快速起搏致心力衰竭犬的心室电生理特性
- Author:
Shuxian ZHOU
;
Wei WU
;
Yuling ZHANG
;
Juan LEI
;
Xuming ZHANG
- Publication Type:Journal Article
- Keywords:
Heart failure,congestive;
Electrophysiology;
Action potentials;
Ventricular fibrillation;
Hemodynamics
- From:
Chinese Journal of Pathophysiology
2007;23(11):2116-2121
- CountryChina
- Language:Chinese
-
Abstract:
AIM:To research the characteristics of ventricular electrophysiology in right ventricular rapid pacing-induced congestive heart failure (CHF) dogs. METHODS:Dogs (n = 16) were randomly divided into 2 groups:the control (n = 7) and the CHF group (n = 9) induced by rapid right ventricular pacing at 240 pulse·min-1 for 4 to 5 weeks. The electrophysiologic parameters were evaluated by the technique of standard electric stimulation and monophasic action potential (MAP) recording. RESULTS:(1) Ventricular effective refractory period (VERP), ventricular MAP duration (MAPD90), ventricular late repolarization duration (VLRD) and intra- ventricular conduction time (IVCT) were prolonged by 26％ (P ＜ 0. 01), 43％ (P ＜ 0. 01), 318％ (P ＜ 0. 05), and 19％ (P ＜ 0. 01), respectively in CHF group. (2)The ratio of VERP to MAPD90(VERP/MAPD90) was decreased by 13％ (P＜0.05) in CHF group. (3) The dispersion of ventricular recovery time (VRT - D) was increased by 185％ (P ＜0. 01) in CHF group. (4) The ventricular fibrillation threshold (VFT) was decreased by 48％ (P ＜ 0. 01) in CHF group. CONCLUSION:The abnormal electrophysiological changes in the CHF condition may be contributing factors of lethal ventricular arrhythmias and sudden cardiac deaths in CHF.
