NF-κBp50 is Associated With DC-SIGN Expression Induced by IL-4 in THP-1 Cells
- VernacularTitle:NF-κBp50参与IL-4在THP-1细胞中诱导DC-SIGN的表达
- Author:
Lijun XU
;
Xiuchun CHANG
;
Hangping YAO
;
Nanping WU
- Publication Type:Journal Article
- Keywords:
NF-κB p50;
DC-SIGN;
IL-4;
THP-1 cell
- From:
Progress in Biochemistry and Biophysics
2008;35(1):50-55
- CountryChina
- Language:Chinese
-
Abstract:
DC-specific intercellular adhesion molecule-3-grabbing nonintegrin (DC-SIGN) is specific receptor on Dendritic cells, and plays a pivotal role on antigens presentation. Uptodate, the clear regulation mechanisms for DC-SIGN expression are not available.IL-4 is one of the most important cytokines inducing DC-SIGN production, while, NF-κB is an important transcription factor controlling signaling transduction. Both IL-4 and NF-κB are closely related to DC-SIGN regulation. NF-κB and IL-4 actions on DC-SIGN promoter activity, DC-SIGN expression as well as interactions between IL-4 and NF-κB were investigated in THP-1 cell. It was found that the mutation of NF-κB binding site in DC-SIGN promoter results in DC-SIGN promoter activity decrease about 50%.NF-κBp50 stimulates DC-SIGN expression in THP-1 cells. IL-4 upregulates DC-SIGN expression on THP-1 cells as well as NF-κB production. These data reveal that NF-κB is associated with IL-4 induced DC-SIGN expression.
