Relationship between follicular development and insulin like growth factor Ⅰ receptor in stimulated cycles
- VernacularTitle:超排卵时卵泡发育数与颗粒细胞胰岛素样生长因子Ⅰ受体的表达
- Author:
Danqing CHEN
;
Yifu SHI
;
Huaizeng CHEN
- Publication Type:Journal Article
- From:
Chinese Journal of Obstetrics and Gynecology
2001;36(2):98-100
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the number of follicles and insulin-like growth factor I receptor (IGF-ⅠR) in stimulated cycles. Method IGF-ⅠR mRNA and IGF-ⅠR in granulosa cells obtained during oocyte retrieval were respectively measured by reverse transcript polymerase chain reaction （RT-PCR） and Western blot technique. Results The expression of IGF-ⅠR mRNA in poor responders (follicles≤3) was much lower than in normal responders (follicles 4～13) and high responders (follicles≥14) (1.70±0.23, 2.92±0.49,4.22±1.50 respectively). Similar results were obtained for IGF-ⅠR (1.32±0.31, 2.01±0.72, 4.39±2.31 respectively). Conclusion The expression of IGF-ⅠR correlated with the effects of gonadotropin hormone on follicular development.
