Therapeutic effect of topiramate on infantile spasms
10.3760/cma.j.issn.1008-6706.2011.02.005
- VernacularTitle:托吡酯联合多种药物治疗婴儿痉挛症疗效观察
- Author:
Zhongmin YOU
- Publication Type:Journal Article
- Keywords:
Infantile spasms;
Topiramate;
Muti-medicine;
Clinical investigation
- From:
Chinese Journal of Primary Medicine and Pharmacy
2011;18(2):155-156
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the clinical effects of topiramate together with low-dose ACTH and prednisone、vitamine B6、gamma globulin on infantile spasms. Methods 134 infantile spasms patients were selected and randomly divided into control group and treatment group, each group 67 patients. The control group was treated with sodium valproate. The treatment group received low-dose ACTH and prednisone、topiramate、vitamine B6 、gamma globulin. The two groups all completed a therapeutic period of 3 months. Results The effect of the treatment group compared with the control group has significantly statistical difference (P ＜ 0.05) ;the result of the treatment group'electroencephalogran compared with that of the control group also has significants difference (P ＜ 0.05). Conclusion The therapeutic effect of low-dose ACTH and prednisone、 topiramate、 vitamine B6、 gamma globulin together on infantile spasms was much better than just taking sodium valproate only.
