Recent Advances in Research on Hepadnaviral Infection in the Woodchuck Model
- Author:
Ina SCHULTE
;
Ejuan ZHANG
;
Zhongji MENG
;
Rongjuan PEI
;
Mengji LU
;
Michael ROGGENDORF
- Publication Type:Journal Article
- Keywords:
Chronic hepatitis B;
Woodchuck hepatitis virus (WHV);
Hepatitis B virus (HBV)
- From:
Virologica Sinica
2008;23(2):107-115
- CountryChina
- Language:Chinese
-
Abstract:
The woodchuck model is an excellent animal model to study hepadnaviral infection. The new progresses in this model made possible to examine the T-cell mediated immune responses in acute and chronic hepadnaviral infection. Recently, a new assay for cytotoxic T-cells based on detection of CD107 was established for the woodchuck model. In addition, new immunotherapeutic approaches based on combination of potent antiviral treatment and DNA-protein vaccines were proven to be useful for treatment of chronic hepatitis B.
