Anti-Hepatitis B Virus Drugs in Clinical and Preclinical Development
- Author:
Guifeng WANG
;
Liping SHI
;
Jianping ZUO
- Publication Type:Journal Article
- Keywords:
Anti-HBV drugs;
Immunomodulatory agents;
HBV
- From:
Virologica Sinica
2008;23(2):137-145
- CountryChina
- Language:Chinese
-
Abstract:
Up to date, there are two types of drugs approved to treat hepatitis B: interferons and nucleos (t) ide analogues. However, the therapies are limited in the clinical context because of the negative side effects of interferon-α and the development of substantial viral resistance to nucleos (t) idic inhibitors. Therefore, new drugs with novel structures and mechanisms are needed. In this article, the drugs approved by FDA or the European Commission for treating chronic hepatitis B virus infection, as well as those under clinical trials, and several compounds in preclinical studies are reviewed. Additionally, some potential targets and strategies to combat chronic hepatitis B virus infection are discussed.
