Biological Effects of HBV X Protein on Hepatocellular Carcinogenesis in Association with Cellular Factors
- Author:
Shiqun WANG
;
Jianguo WU
- Publication Type:Journal Article
- Keywords:
Human hepatitis B virus (HBV);
Ras;
YueF;
Hepatocellular carcinoma
- From:
Virologica Sinica
2008;23(2):146-151
- CountryChina
- Language:Chinese
-
Abstract:
The X protein (HBx) of Human hepatitis B virus (HBV) acts as an indirect transcriptional transactivator to regulate the expression of many viral and cellular genes, as well as playing a critical role in pathogenesis and the development of Hepatocellular carcinoma (HCC). Here we described the biological effects of HBx in association with four cellular factors, including inflammatory factors (COX-2 and iNOS), oncoprotein (Ras), and a newly identified tumor suppressor (YueF). The characteristics of these effectors, which might be associated with hepatocellular carcinoma, are also discussed.
