Clinical Implication of Magnetic Resonance Imaging in the Idiopathic Inflammatory Myopathies.
- Author:
Jae Hyun KOH
1
;
Suk Joo HONG
;
Hong Joon AHN
;
Joong Kyung AHN
;
Chan Hong JEON
;
Hoon Suk CHA
;
Joong Mo AHN
;
Hyun Sook KIM
;
Yeon Lim SEO
;
Eun Mi KOH
Author Information
1. Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea. dockoh@samsung.co.kr
- Publication Type:Original Article
- Keywords:
Magnetic resonance imaging;
Muscle;
Biopsy;
Polymyositis;
Dermatomyositis
- MeSH:
Biopsy;
Dermatomyositis;
Female;
Humans;
Magnetic Resonance Imaging*;
Myositis*;
Necrosis;
Polymyositis;
Quadriceps Muscle;
Regeneration;
Subcutaneous Fat
- From:The Journal of the Korean Rheumatism Association
2002;9(3):159-168
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
OBJECTIVE: The purpose of the study is to describe the magnetic resonance imaging (MRI) findings and to investigate useful sequences of MRI in inflammatory myopathies. A third goal is to correlate MRI findings with the grade of histopathologic severity. METHODS: Sixteen patients (13 women, 3 men), aged 21-74 years (median age of 49) with inflammatory myositis (examined with both MRI and muscle biopsy) were studied. Ten patients were diagnosed with polymyositis and 6 with dermatomyositis. Conventional T1-weighted (SE 366/12) and T2-weighted (SE 4766/90) fast spin-echo and fat-suppressed T1-weighted MR images with contrast enhancement (FSAT T1 CE) were obtained. Ratios between the signal intensities of a muscle and the signal intensities of subcutaneous fat in the same tomographic sections were calculated to objectively represent the degree of signal intensities. Semi-quantitative grading of severities in muscle biopsy specimen was examined based on invasion of inflammatory cells and necrosis, degeneration and regeneration of muscle fiber by a neuromuscular pathologist. RESULTS: FSAT T1 CE could objectively describe the severity of involvement in inflammatory myopathies. The quadriceps muscle group, especially the vastus muscle tended to be most severely and frequently involved in inflammatory myositis with FSAT T1 CE (statistically insignificant). The vastus intermedius muscle was more severely involved in dermatomyositis than polymyositis. The signal intensity of abnormal muscle sampled by biopsy correlated positively with the grade of muscle biopsy. CONCLUSION: MRI shows promise in identifying pathologic muscle in patients suspected of having one of the inflammatory myopathies. The degree of signal intensity on MRI may reflect the severity of grade in muscle biopsy.
