5-HT2A receptor gene polymorphism and negative symptoms in first episode (drug-naive) Chinese Han nationality individuals with schizophrenia
- VernacularTitle:中国首次发作的精神分裂症患者5-HT2A受体基因多态性与阴性症状的关系
- Author:
Yuhong WANG
;
Wenqiang LI
;
Zhao HUANG
;
Yuzhong SHI
;
Xuyi WANG
;
Jinsong HUANG
;
Xuhui ZHOU
;
Hongxian CHEN
;
Wei HAO
;
Liwen CHEN
- Publication Type:Journal Article
- Keywords:
schizophrenia;
5 - hydroxytryptamine 2 A receptor;
gene polymorphism;
nega-tive symptoms;
Han nationality;
Chinese
- From:
Journal of Central South University(Medical Sciences)
2008;33(4):293-298
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate whether the 5-hydroxytryptamine 2A receptor (5-HT2A)gene T102 C polymorphism is associated with the severity symptoms and negative symptoms in the first episode Chinese Han nationality patients with schizophrenia. Methods Altogether 201 first episode Chinese Han nationality patients with schizophrenia were enrolled in this study. Genotyping of 5-HT2A gene T102 C polymorphism was performed by PCR-RFLP technique. The positive and negative Symptom Scale ( PANSS ) was used for the evaluation of the severity of psychotic symptoms before any drug treat-ment. Results 5-HT2A receptor 102-T/T genotype was significantly associated with both the PANSS total and negative symptom subscale baseline scores before the treatment, but not with the positive and general psychopathology subscales. Conclusion 5-HT2A T102 C functional polymorphism may play a role in negative symptoms and prognosis of Chinese Han nationality people with schizophrenia.
