Behavioral comparation on withdrawal syndromes in morphine dependent rats
- VernacularTitle:吗啡依赖大鼠模型的戒断行为学比较
- Author:
Zhi CHEN
;
Hua FENG
- Publication Type:Journal Article
- From:Chinese Journal of Behavioral Medicine and Brain Science
2001;10(1):11-12
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the the effect and interaction of morphine dependence model and naloxone doses on withdrawal intensity. Methods To observe the withdrawal signs and weight loss in two kinds of morphine dependent rats after the precipitating by naloxone of different doses an devaluate the withdrawal intensity.Results Morphine dependence were successfully induced in two ways.There was no significant difference of withdrawal intensity in five-day model(total morphine dose 380mg.kg－1) after precipitating by naloxone of 2mg.kg－1 and 4mg.kg－1（P＞0.05）. Withdrawal intensity of twelve-day model(total morphine dose 1365mg.kg－1)increased significantly with the increase of naloxone dose（P＜0.01）,but it was more intensive significantly than five-day model only after 4mg.kg－1 dose of naloxone. Conclusion Appropriate method should be used to induce morphine dependence and these experimental factors should be combined in assessment of withdrawal intensity.
