RO-Heparin Inhibits β2-Integrin(Mac-1)-mediated Neutrophils Adhesion
- VernacularTitle:高碘酸氧化肝素抑制β2-整合素(Mac-1)介导的嗜中性粒细胞黏附
- Author:
Zhihong CHEN
;
Yajie JING
;
Xiaoguang WANG
;
Xianlu ZENG
- Publication Type:Journal Article
- Keywords:
RO-heparin;
β2-integrin (Mac-1);
human umbilical endothelial cells (HUVECs);
inflammation
- From:
Progress in Biochemistry and Biophysics
2008;35(6):695-702
- CountryChina
- Language:Chinese
-
Abstract:
The adhesion of leukocytes to vascular endothelium is crucial for the generation of inflammatory responses. The selectinsand β2-integrin (Mac-1) play a major role in the process. Recently, it was reported that RO-heparin can inhibit selectin-mediated leukocyte adhesion. The effect of RO-heparin on the Mac-1-mediated neutrophils adhesion were further tested. The results showed that RO-heparin could effectively inhibit neutrophils binding to ICAM-1, adhering to COS-7 cells expressing human ICAM-1, and adheringto human umbilical vein endothelial cells (HUVECs) under static and flow conditions. The findings suggest that the effect of RO-heparin on leukocyte adhesion is mainly due to its inhibition on the interaction between selectins or Mac-1 and their ligands and that RO-heparin might be useful in preventing inflammation diseases.
