The Expression of Adhesion Molecules in Experimental Allergic and Chemical Conjunctivitis.
- Author:
Hee Bae AHN
1
;
Sae Heun RHO
;
Young Hyun YOO
Author Information
1. Department of Ophthalmology, College of Medicine, Dong-A University, Pusan, Korea.
- Publication Type:Original Article
- Keywords:
C48/80;
AgNO3Allergy and chemical conjunctivitis;
Adhesion molecules
- MeSH:
Animals;
Antigens, CD31;
Blepharospasm;
Cell Adhesion Molecules;
Conjunctivitis*;
Conjunctivitis, Allergic;
Endothelial Cells;
Inflammation;
Intercellular Adhesion Molecule-1;
Mice;
Vascular Cell Adhesion Molecule-1
- From:Journal of the Korean Ophthalmological Society
1998;39(10):2254-2264
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
The purpose of this study was to assess the expression of ICAM-1, VCAM-1 and PECAM-1 in allergic and chemical conjunctivitis. The allergic and chemical conjunctivitis were induced in C57BL/6 mouse by compound 48/80(C48/80) and 2% characterized clinically by blepharospasm 100%, chemosis 80%, injection AgNO3, respectively. The allergic conjunctivitis was characterized clinically by blepharospasm 100%, chemosis 80%, injection, 40%, mucous discharge 20%, but the chemical conjunctivitis by blepharospasm 80%, chemosis 60%, infection 40% and no mucous discharge at 30 minute after topical application. On the endothelial cells, ICAM-1 was expressed from 1 to 48 hours, VCAM-1 from 6 to 72 hours and PECAM-1 from 1 to 72 hours in allergic conjunctivitis. In chemical conjuctivitis, the expression of ICAM-1 was observed from 6 to 72 hours. The expression of VCAM-1 was observed from 24 and 72 hours. The expression of PECAM-1 was demonstrated from 6 to 72 hours. The expression of cell adhesion molecules, particulary VCAM-1 and PECAM-1, was slighter in chemical conjunctivitis compared to allergic conjunctivitis. In conclusion, experimental allergic and chemical conjunctivitis demonstrate that cell adhesion molecules play a role in part in ocular inflammation and that there are differences between the adhesion molecule expression of two types of confunctivitis.
