Hepatocyte transplantation for treatment of hepatic failure
- VernacularTitle:肝细胞移植治疗肝衰竭的研究现状
- Author:
Wenlong YANG
;
Jinqiu HE
;
Xijin ZHOU
- Publication Type:Journal Article
- From:
Chinese Journal of Tissue Engineering Research
2008;12(31):6196-6200
- CountryChina
- Language:Chinese
-
Abstract:
Cell therapy refers to a method that transplants stem cells or differentiated functioning cells into diseased regions to compensate the losing functions of diseased cells or uses the stem cells for treatment of diseases after in vitro genetic manipulation. After more than 30 years of study, great progress in hepatocyte transplantation technique has been acquired. This technique can acquire in situ liver transplantation effects. Hepatocyte transplantation, as an effective method for treatment of fulminant hepatic failure, has been widely confirmed in the animal model experiments and clinical practice. In addition, application of remedial hepatic stem cells can solve the problems regarding the source, number and immune rejection of hepatocytes, and offers a wide prospect for treatment of acute and chronic liver diseases. There are many problems about the study on hepatic stem cells. Up to date, many manuscripts addressing animal hepatic stem cell transplantation have been found, but few of them focus on the case report of treatment of liver disease by hepatocyte transplantation. Therefore, study on hepatic stem cells is still in its initial stage. The study methods should be developed and improved.
